Pesquisa

Aqui você encontrará informações sobre as atividades de pesquisa do LABFAR

As atividades de pesquisa estão alicerçadas nas seguintes linhas de pesquisa:

  1. Desenvolvimento biofarmacêutico de sistemas nanoparticulados
  2. Avaliação farmacocinética e farmacodinâmica de novas moléculas e candidatos a fármacos

Os trabalhos já publicados estão descritos abaixo.

Caso você tenha interesse em receber ou copia do trabalho ou maiores informações relacionadas as linhas de pesquisa, escreva para sandrahaas@unipampa.edu.br

2020

1.NAKAMA, K. A. ; SANTOS, R. B. ; Silva, C.E.R ; IZOTON, J. C. ; SAVALL, A. S. ; GUTIERREZ, M. E. Z. ; ROMAN, S. S. ; LUCHESE, C. ; PINTON, S. ; HAAS, S. E. . Establishment of analytical method for quantification of anti-inflammatory agents co-nanoencapsulated and its application to physicochemical development and characterization of lipid-core nanocapsules. Arabian Journal of Chemistry, v. 13, p. 2456-2469, 2020.

2.DE GOMES, MARCELO GOMES ; PANDO PEREIRA, MURIEL ; GUERRA TEIXEIRA, FLAVIA ELIZABETE ; CARVALHO, FELIPE ; PINTO SAVALL, ANNE SUELY ; FERREIRA BICCA, DIOGO ; MONTEIRO FIDELIS, EDUARDA ; BOTURA, PAULO EMILIO ; WEBER CIBIN, FRANCIELLI ; PINTON, SIMONE ; HAAS, SANDRA ELISA . Assessment of unloaded polymeric nanocapsules with different coatings in female rats: Influence on toxicological and behavioral parameters. BIOMEDICINE & PHARMACOTHERAPY, v. 121, p. 109575, 2020.

3.ABREU, E. L. ; GUTIERREZ, M. E. Z. ; SAVALL, A. S. ; NAKAMA, K. A. ; SANTOS, R. B. ; DAVILA, D. S. ; LUCHESE, C. ; QUINES, C. ; HAAS, S. E. ; PINTON, S. . Co-nanoencapsulated meloxicam and curcumin improves cognitive impairment induced by amyloid-beta through modulation of COX-2 in mice. Neural Regeneration Research, 2020.

4.GIACOMELLI, R. ; DE GOMES, MARCELO GOMES ; COLOME, L. M. ; HAAS, S. E. ; JESSE, C. R. . Chrysin loaded lipid-core nanocapsules ameliorates neurobehavioral alterations induced by β-amyloid1-42 in aged female mice. BEHAVIOURAL BRAIN RESEARCH, 2020.

5.DE GOMES, MARCELO GOMES ; GUERRA, F. E. ; CARVALHO, F. B. ; NETO, M. ; PACHECO, C. O. ; SANTOS, R. B. ; GIACOMELLI, R. ; CAMPOS, V. F. ; HAAS, S. E. . Curcumin-loaded lipid-core nanocapsules attenuates the immune challenge LPS-induced in rats: Neuroinflammatory and behavioral response in sickness behavior. JOURNAL OF NEUROIMMUNOLOGY, 2020.

6. GIACOMELI, R; TEIXEIRA, F. E. G; CARVALHO, F. B; PACHECO, C. O; PARISOTTO, A. J. M; RIBEIRO, A. C. F; DE GOMES, M.G; HAAS, S. E. (2020). Curcumin-loaded poly (ɛ-caprolactone) lipid-core nanocapsules: Evaluation of fetal and maternal toxicity. Food and Chemical Toxicology, 111625.

 

2019

1.RONCATO, J. ; CAMARA, D. ; BRUSSOLO, T. ; QUINES, C. ; COLOME, L. M. ; DENARDIN, CRISTIANE C. ; HAAS, S. E. ; DAVILA, D. S. . Lipid reducing potential of liposomes loaded with ethanolic extract of purple pitanga ( Eugenia uniflora) administered to Caenorhabditis elegans. JOURNAL OF LIPOSOME RESEARCH, p. 1-9, 2019.
2.REOLON, JÉSSICA BRANDÃO ; BRUSTOLIN, MAICON ; ACCARINI, THAINÁ ; VIÇOZZI, GABRIEL PEDROSO ; SARI, MARCEL HENRIQUE MARCONDES ; BENDER, EDUARDO ANDRÉ ; HAAS, SANDRA ELISA ; BRUM, MARIO CELSO SPERROTTO ; GÜNDEL, ANDRÉ ; COLOMÉ, LETÍCIA MARQUES . Co-encapsulation of acyclovir and curcumin into microparticles improves the physicochemical characteristics and potentiates in vitro antiviral action: Influence of the polymeric composition. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, v. 131, p. 167-176, 2019.
 3.PEREIRA, MURIEL PANDO ; DE GOMES, MARCELO GOMES ; IZOTON, JESSICA CRISTINA ; NAKAMA, KELLY AYUMI ; DOS SANTOS, RENATA BEM ; PINTO SAVALL, ANNE SUELY ; RAMALHO, JULIANA BERNERA ; ROMAN, SILVANE SOUZA ; LUCHESE, CRISTIANE ; CIBIN, FRANCIELLI WEBER ; PINTON, SIMONE ; HAAS, SANDRA ELISA . Cationic and anionic unloaded polymeric nanocapsules: Toxicological evaluation in rats shows low toxicity. BIOMEDICINE & PHARMACOTHERAPY, v. 116, p. 109014, 2019.
4.GIACOMELLI, R. ; IZOTON, J. C. ; SANTOS, R. B. ; BOEIRA, S. P. ; JESSE, C. R. ; HAAS, S. E. . Neuroprotective effects of curcumin lipid-core nanocapsules in a model Alzheimer’s disease induced by -amyloid 1-42 peptide in aged female mice. BRAIN RESEARCH, v. 1721, p. 146325, 2019.
5.DE GOMES, MARCELO GOMES ; DEL FABBRO, LUCIAN ; GOES, ANDRÉ ROSSITO ; SOUZA, LEANDRO CATTELAN ; BOEIRA, SILVANA PETERINI ; HAAS, SANDRA ELISA ; PUNTEL, ROBSON LUIZ ; JESSE, CRISTIANO RICARDO . Supplementation with gamma oryzanol ameliorates CCl4-induced hepatic fibrosis in mice. PHARMANUTRITION, v. XX, p. 100169, 2019.
6.NAKAMA, K. A. ; SANTOS, R. B. ; SERPA, P. ; MACIEL, T. R. ; HAAS, S. E. . Organoleptic excipients used in pediatric antibiotics. ARCHIVES DE PEDIATRIE, p. 1, 2019.
7.FIDELIS, E. M. ; SAVALL, A. S. P. ; ABREU, E. L. ; CARVALHO, F. B. ; GUERRA, F. E. ; HAAS, S. E. ; SAMPAIO, T. B. ; PINTON, S. . CURCUMIN-LOADED NANOCAPSULES REVERSES THE DEPRESSANT-LIKE BEHAVIOR AND OXIDATIVE STRESS INDUCED BY -AMYLOID IN MICE. NEUROSCIENCE, v. xx, p. xx, 2019.
8.Michels, L.R. ; MACIEL, T. R. ; NAKAMA, K. A. ; GUERRA, F. E. ; CARVALHO, F. B. ; GUNDEL, A. ; ARAUJO, Bibiana ; HAAS, S. E.  Effects of Surface Characteristics of Polymeric Nanocapsules on the Pharmacokinetics and Efficacy of Antimalarial Quinine

. International Journal of Nanomedicine, v. Volume 14, p. 10165-10178, 2019.

9. FUNGHETTO, A. C. ; PEREIRA, M. P. ; PIEGAS, E. M. ; FREDDO, R.J. ; HAAS, S. E. . Development of alternative activities to animal use in pharmacology education. ENSINO & PESQUISA, v. 17, p. 1, 2019.

 

2018

1.MACIEL, T. R. ; Michels, L.R. ; PIEGAS, E. M. ; HAAS, S. E. . PROMOTION OF NANOSCIENCE & NANOTECHNOLOGY POPULARIZATION FOR HIGH SCHOOL STUDENTS. INTERCIENCIA, v. 43, p. 92, 2018.

2.IZOTON, J. C. ; MACIEL, TAMARA ; LORENSET, A. ; PEREIRA, M. P. ; HAAS, S. E. . The use of Daphnia magna for the toxicological evaluation of inorganic nanoparticles. CURRENT TOPICS IN TOXICOLOGY, v. 13, p. 113-125, 2018.
3.REOLON, J. B. ; BRUSTOLIN, M. ; HAAS, S. E. ; BENDER, E. A. ; MALEIZUIK, M. D. ; COLOME, L. M. . Development and validation of high-performance liquid chromatography method for simultaneous determination of acyclovir and curcumin in polymeric microparticles. JOURNAL OF APPLIED PHARMACEUTICAL SCIENCE, v. 8, p. 136, 2018.
4. PEREIRA, K.V. ; MACIEL, T. R. ; GUERRA, F. E. ; FORNO, ANA HELENA DAL ; FONSECA, A. L. ; VAROTTI, F. ; FAJARDO, A. R. ; DAVILA, D. S. ; HAAS, S. E. . Co-nanoencapsulation of antimalarial drugs increases their in vitro efficacy against Plasmodium falciparum and decreases their toxicity to Caenorhabditis elegans. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, v. 118, p. 1-12, 2018.
5.WILHELM, E. ; VOGT, A. ; REIS, A. ; PINZ, M. ; SOUZA, J. ; HAAS, S. E. ; PEREIRA, A. ; FAJARDO, A. R. ; LUCHESE, C. . The efficacy of microemulsion-based delivery to improve vitamin E properties: evaluation of the antinociceptive, antioxidant, antidepressant- and anxiolytic-like activities in mice. JOURNAL OF PHARMACY AND PHARMACOLOGY, v. 70, p. 1723-1732, 2018.
2017
1.BAJERSKI, LISIANE ; HAAS, SANDRA ; MACIEL, TAMARA . Simultaneous determination of curcumin and quinine co-encapsulated in nanoemulsions by stability-indicating LC method. Current Pharmaceutical Analysis, v. 13, p. 1-1, 2017.
2.SHEURER, G. ; MACIEL, TAMARA ; PIEGAS, E. M. ; Michels, L.R. ; COLOME, L. M. ; FREDDO, R.J. ; DAVILA, D. S. ; GUNDEL, A. ; HAAS, S. E. . Optimization of Curcuma Oil/Quinine-Loaded Nanocapsules for Malaria Treatment. AAPS PHARMSCITECH, p. 1-14, 2017.
3.MORAES, B.K.S. ; IZOTON, J. C. ; JOHANSSON, F. A. ; AMARAL, M. ; FREDDO, R.J. ; BARREIRO, E.J. ; COSTA, Teresa Dalla ; LIMA, L. M. ; HASS, SANDRA ELISA . Leishmanicidal candidate LASSBio-1736, a cysteine protease inhibitor with favorable pharmacokinetics: low clearance and good distribution. XENOBIOTICA, v. 27, p. 1-10, 2017.
4.COLOME, L. M. ; FREITAS, G. M. ; BASTIANI, J. M. ; PEREIRA, T. C. B. ; BAJERSKI, L. ; BENDER, E. A. ; HAAS, S. E. . Validation of analytical method by HPLC for determination of dapsone in polymeric nanocapsules based on crude rice brain oil. JOURNAL OF APPLIED PHARMACEUTICAL SCIENCE, p. 230, 2017.
2016.
1.MORAES, B.K.S. ; VIEIRA, S. ; SALGUEIRO, W. ; Michels, L.R. ; COLOME, L. M. ; DAVILA, D. S. ; HAAS, S. E. . Clozapine-Loaded Polysorbate-Coated Polymeric Nanocapsules: Physico-Chemical Characterization and Toxicity Evaluation in Caenorhabditis elegans Model. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, v. 16, p. 1257-1264, 2016.
2. PEREIRA, K.V. ; Michels, L.R. ; COLOME, L. M. ; HAAS, S. E. . Educational Activities for Rural and Urban Students to Prevent Skin Cancer in Rio Grande do Sul, Brazil. Asian Pacific Journal of Cancer Prevention, v. 17, p. 1201-1207, 2016.
3. MORAES, B.K.S. ; BAJERSKI, L. ; PARISOTO, A. ; Silva, C.E.R ; AMARAL, M. ; BARREIRO, E.J. ; FREDDO, R.J. ; COSTA, Teresa Dalla ; LIMA, L. M. ; HAAS, S. E. . Simple HPLC-UV for the quantification of a new leishmanicidal candidate (E)-1-4 (trifluoromethyl) benzylidene) – 5 – (2-4-dichlorozoyl) carbonylhydrazine (LASSBio-1736) in rat plasma for pharmacokinetics assessment. BMC. Biomedical Chromatography, v. 30, p. 1029-n/a, 2016.
4.Michels, L.R. ; BAJERSKI, L. ; MACIEL, T. R. ; COLOME, L. M. ; HAAS, SANDRA ELISA . Quinine-Loaded Polymeric Nanoparticles: Validation of a simple HPLC-PDA Method to Determine Drug Entrapment and Evaluation of Its Photostability. Journal of Applied Pharmaceutical Science, v. 6, p. 009-015, 2016.
5. FORNO, ANA HELENA DAL ; CÂMARA, DANIELA ; PARISE, BRUNA ; RODRIGUES, CRISTIANE F ; SOARES, JEFFERSON J. ; WAGNER, ROGER ; RIBEIRO, STEPHANIE R. ; FOLMER, VANDERLEI ; PUNTEL, ROBSON ; HAAS, SANDRA E. ; FARIAS, FABIANE M. ; DENARDIN, ELTON L.G. ; DENARDIN, CRISTIANE C. ; AVILA, DAIANA SILVA . Antioxidant and Lipid Lowering Effects of Pterodon emarginatus Oil obtained from dried fruits in Caenorhabditis elegans. Arabian Journal of Chemistry, v. xx, p. xx, 2016.
5.VIEIRA, SIMONE MACHADO ; Michels, L.R. ; ROVERSI, K. ; METZ, V. G. ; MORAES, B.K.S. ; PIEGAS, E. M. ; FREDDO, R.J. ; GUNDEL, A. ; COSTA, Teresa Dalla ; BUERGER, M. ; COLOME, L. M. ; HAAS, S. E. . A surface modification of clozapine-loaded nanocapsules improves their efficacy: a study of formulation development and biological assessment. Colloids and Surfaces. B, Biointerfaces (Print), v. 145, p. 748-756, 2016.
6.BAJERSKI, L. ; Michels, L.R. ; COLOME, L. M. ; BENDER, E. A. ; FREDDO, R.J. ; BRUXEL, F. ; HAAS, SANDRA E. . The use of Brazilian vegetable oils in nanoemulsions: an update on preparation and biological applications. Brazilian Journal of Pharmaceutical Sciences (Online) v. 52, p. 347-363, 2016.
7.IZAGUIRRY, A. P. ; PAVIN, N. F. ; SOARES, M. B. ; SPIAZZI, C. C. ; ARAUJO, F. A. ; Michels, L.R. ; LEIVAS, F. G. ; BRUM, D. S. ; HAAS, S. E. ; SANTOS, F. W. . Effect of quinine-loaded polysorbate-coated nanocapsules on male and female reproductive systems of rats. Toxicology Research, v. 5, p. 1561-1572, 2016.
2015.
1. JOHANSSON, F. A. ; HAAS, S. E. ; SANSONE, P. E. S. ; DERENDORF, H. ; COSTA, Teresa Dalla ; ARAUJO, Bibiana . Does the Anesthetic Urethane Influence the Pharmacokinetics of Antifungal Drugs? A Population Pharmacokinetic Investigation in Rats. Journal of Pharmaceutical Sciences, v. 104, p. 3314-3318, 2015.
2. FORESTI, G. R. ; BECKER, N. ; SILVA, A. S. ; ALMEIDA, W. R. R. ; HAAS, S. E. ; MALEIZUIK, M. D. ; SILVA, F. B. . An Alternative Method for the Dissolution of Enrofloxacin Tablets. Dissolution Technologies, v. 22, p. 23-27, 2015.
2014
1.FOLETTO, M. C. ; HAAS, S. E. . Melanoma skin cancer: new advances in the treatment. Anais Brasileiros de Dermatologia (Impresso), v. 89, p. 118-125, 2014.
2. Torres, B.G.S. ; UCHôA, F. D. ; PIGATTO, M. ; JOHANSSON, F. A. ; HAAS, S. E. ; DALLEGRAVE, E. ; CANTO, R. F. ; EIFLER-LIMA, V. ; COSTA, Teresa Dalla . Pre-Clinical Pharmacokinetics and Acute Toxicological Evaluation of a Monastrol Derivative Anticancer Candidate LaSOM 65 in Rats. Xenobiotica (London. Print), v. 44, p. 254-263, 2014.
3. HAAS, S. E.; ANDRADE, C. ; SANSONE, P. E. S. ; GUTERRES, Silvia ; COSTA, Teresa Dalla . Development of innovative oil-core self-organized nanovesicles prepared with chitosan and lecithin using a 2x2x2 full-factorial design. Pharmaceutical Development and Technology (Print), v. 19, p. 769-778, 2014.
4.ANDRADE, C. ; LOCK, G. ; PIGATTO, M. ; HAAS, S. E. ; COSTA, Teresa Dalla ; ARAUJO, Bibiana . Validation of LC-MS/MS method applied to evaluation of free tissue concentrations of vildagliptin in diabetic rats by microdialysis. BMC. Biomedical Chromatography, v. 1, p. n/a-n/a, 2014.
5. DA COSTA GÜLLICH, ANGÉLICA APARECIDA ; COELHO, RITIÉLE PINTO ; PILAR, BRUNA COCCO ; STRÖHER, DEISE JAQUELINE ; GALARÇA, LEANDRO ALEX SANDER LEAL ; VIEIRA, SIMONE MACHADO ; DA COSTA ESCOBAR PICCOLI, JACQUELINE ; HAAS, SANDRA ELISA ; MANFREDINI, VANUSA . Clozapine linked to nanocapsules minimizes tissue and oxidative damage to biomolecules lipids, proteins and DNA in brain of rats Wistar. Metabolic Brain Disease, v. 30, p. 695-702, 2014.